Exploring GPs' perspectives about using N-of-1 trials in general practice

About this study

The randomised controlled trial (RCT) is recognised as the “gold standard” design for evaluating interventions. RCTs tell us whether a treatment is effective on average, but not whether it is effective for an individual patient. In contrast, N-of-1 trials are multiple crossover, randomised controlled trials of treatments versus a placebo (or another treatment) in a single patient that can be used to determine treatment response at the individual patient level. Individualised findings from N-of-1 trials provide greater precision in treating compared to the informal ‘trial-and-error’ approach. 

This study aims to explore General Practitioners' perspectives about the barriers and facilitators to using N-of-1 trials in general practice. The findings from the study will be used to inform strategies to increase awareness and uptake of N-of-1 trials in general practice. 

This study is embedded within a larger programme or research that explores various stakeholders' perspectives about using N-of-1 trials and single-case designs in the context of healthcare. Stakeholders groups include health professionals (e.g. GPs, psychologists, physiotherapists), patients, trialists/methodologists, biostatisticians, journal editors, ethics board members and health research funders. To find out more about this programme of research, please visit the study wepbage. 

Participting in the study

If you are a GP who is interested in participating in this study, please read the study flyer for more information.

Prinicipal investigator

Dr Suzanne McDonald

Research Fellow
General Practice Clinical Unit
Honorary Research Fellow
UQ Centre for Clinical Research

Co-investigators

Dr David King

Dr David King

Senior Lecturer
General Practice Clinical Unit
Dr Jane Nikles

Dr Jane Nikles

Senior Research Fellow
UQ Centre for Clinical Research