Dr Julia Pagan

Featured projects	Duration
Multiple projects in molecular and cell biology related to cancer research

Pagan, Julia, Bolderson, Emma, Jones, Mathew and Khanna, Kum Kum (2009). Chromatin modifications involved in the DNA damage response to double strand breaks. DNA damage response: implications on cancer formation and treatment. (pp. 109-131) edited by Kum Kum Khanna and Yosef Shiloh. New York, NY, United States: Springer. doi: 10.1007/978-90-481-2561-6_6

Dhar, Krishayant S., Townsend, Brendan, Montgomery, Andrew P., Danon, Jonathan J., Pagan, Julia K. and Kassiou, Michael (2024). Enhancing CNS mitophagy: drug development and disease-relevant models. Trends in Pharmacological Sciences, 45 (11), 982-996. doi: 10.1016/j.tips.2024.09.002

Nguyen-Dien, Giang Thanh, Townsend, Brendan, Kulkarni, Prajakta Gosavi, Kozul, Keri-Lyn, Ooi, Soo Siang, Eldershaw, Denaye N, Weeratunga, Saroja, Liu, Meihan, Jones, Mathew JK, Millard, S Sean, Ng, Dominic CH, Pagano, Michele, Bonfim-Melo, Alexis, Schneider, Tobias, Komander, David, Lazarou, Michael, Collins, Brett M and Pagan, Julia K (2024). PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCFFBXL4. EMBO Reports, 25 (8), 3324-3347. doi: 10.1038/s44319-024-00181-y

Kulkarni, Prajakta, Nguyen-Dien, Giang Thanh, Kozul, Keri-Lyn and Pagan, Julia K. (2024). FBXL4: safeguarding against mitochondrial depletion through suppression of mitophagy. Autophagy, 20 (6), 1-3. doi: 10.1080/15548627.2024.2318077

Niemi, Natalie M., Serrano, Lia R., Muehlbauer, Laura K., Balnis, Catherine E., Wei, Lianjie, Smith, Andrew J., Kozul, Keri-Lyn, Forny, Merima, Connor, Olivia M., Rashan, Edrees H., Shishkova, Evgenia, Schueler, Kathryn L., Keller, Mark P., Attie, Alan D., Friedman, Jonathan R., Pagan, Julia K., Coon, Joshua J. and Pagliarini, David J. (2023). PPTC7 maintains mitochondrial protein content by suppressing receptor-mediated mitophagy. Nature Communications, 14 (1) 6431, 1-17. doi: 10.1038/s41467-023-42069-w

Nguyen‐Dien, Giang Thanh, Kozul, Keri‐Lyn, Cui, Yi, Townsend, Brendan, Kulkarni, Prajakta Gosavi, Ooi, Soo Siang, Marzio, Antonio, Carrodus, Nissa, Zuryn, Steven, Pagano, Michele, Parton, Robert G, Lazarou, Michael, Millard, S Sean, Taylor, Robert W, Collins, Brett M, Jones, Mathew JK and Pagan, Julia K (2023). FBXL4 suppresses mitophagy by restricting the accumulation of NIX and BNIP3 mitophagy receptors. The EMBO Journal, 42 (13) e112767, e112767. doi: 10.15252/embj.2022112767

Ng, Dominic C.H., Richards, Dominic K., Mills, Richard J., Ho, Uda Y., Perks, Hannah L., Tucker, Callum R., Voges, Holly K., Pagan, Julia K. and Hudson, James E. (2020). Centrosome reduction promotes terminal differentiation of human cardiomyocytes. Stem Cell Reports, 15 (4), 817-826. doi: 10.1016/j.stemcr.2020.08.007

Rona, Gergely, Roberti, Domenico, Yin, Yandong, Pagan, Julia K., Homer, Harrison, Sassani, Elizabeth, Zeke, Andras, Busino, Luca, Rothenberg, Eli and Pagano, Michele (2018). PARP1-dependent recruitment of the FBXL10-RNF68-RNF2 ubiquitin ligase to sites of DNA damage controls H2A.Z loading. eLife, 7 e38771. doi: 10.7554/eLife.38771.001

Kuchay, Shafi, Giorgi, Carlotta, Simoneschi, Daniele, Pagan, Julia, Missiroli, Sonia, Saraf, Anita, Florens, Laurence, Washburn, Michael P., Collazo-Lorduy, Ana, Castillo-Martin, Mireia, Cordon-Cardo, Carlos, Sebti, Said M., Pinton, Paolo and Pagano, Michele (2017). PTEN counteracts FBXL2 to promote IP3R3-and Ca2+-mediated apoptosis limiting tumour growth. Nature, 546 (7659), 554-558. doi: 10.1038/nature22965

Pagan, Julia K., Marzio, Antonio, Jones, Mathew J. K., Saraf, Anita, Jallepalli, Prasad V., Florens, Laurence, Washburn, Michael P. and Pagano, Michele (2015). Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing. Nature Cell Biology, 17 (1), 31-43. doi: 10.1038/ncb3076

Skaar, Jeffrey R., Pagan, Julia K. and Pagano, Michele (2014). SCF ubiquitin ligase-targeted therapies. Nature Reviews Drug Discovery, 13 (12), 889-903. doi: 10.1038/nrd4432

Skaar, Jeffrey R., Pagan, Julia K. and Pagano, Michele (2013). Mechanisms and function of substrate recruitment by F-box proteins. Nature Reviews Molecular Cell Biology, 14 (6), 369-381. doi: 10.1038/nrm3582

Pagan, Julia, Seto, Tiffany, Pagano, Michele and Cittadini, Antonio (2013). Role of the ubiquitin proteasome system in the heart. Circulation Research, 112 (7), 1046-1058. doi: 10.1161/CIRCRESAHA.112.300521

Duan, Shanshan, Cermak, Lukas, Pagan, Julia K., Rossi, Mario, Martinengo, Cinzia, di Celle, Paola Francia, Chapuy, Bjoern, Shipp, Margaret, Chiarle, Roberto and Pagano, Michele (2012). FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas. Nature, 481 (7379), 90-94. doi: 10.1038/nature10688

Pagan, Julia and Pagano, Michele (2011). FBXW5 controls centrosome number. Nature Cell Biology, 13 (8), 888-890. doi: 10.1038/ncb2312

Bashir, Tarig, Pagan, Julia K., Busino, Luca and Pagano, Michele (2010). Phosphorylation of Ser72 is dispensable for Skp2 assembly into an active SCF ubiquitin ligase and its subcellular localization. Cell Cycle, 9 (5), 971-974. doi: 10.4161/cc.9.5.10914

Skaar, Jeffrey R., D'Angiolella, Vincenzo, Pagan, Julia K. and Pagano, Michele (2009). SnapShot: F Box Proteins II. Cell, 137 (7), 1358-U100. doi: 10.1016/j.cell.2009.05.040

Arun Gupta, Qin Yang, Raj K. Pandita, Clayton R. Hunt, Tao Xiang, Sandeep Misri, Sicong Zeng, Julia Pagan, Jessie Jeffery, Janusz Puc, Rakesh Kumar, Zhihui Feng, Simon N. Powell, Audesh Bhat, Tomoko Yaguchi, Renu Wadhwa, Sunil C. Kaul, Ramon Parsons, Kum Kum Khanna and Tej K. Pandita (2009). Cell cycle checkpoint defects contribute to genomic instability in PTEN deficient cells independent of DNA DSB repair. Cell Cycle, 8 (14), 2198-2210. doi: 10.4161/cc.8.14.8947

Skaar, Jeffrey R., Pagan, Julia K. and Pagano, Michele (2009). SnapShot: F Box Proteins I. Cell, 137 (6), 1358-U100. doi: 10.1016/j.cell.2009.05.039

Pagan, Julia K., Arnold, Jeremy, Hanchard, Kim J., Kumar, Raman, Bruno, Tiziana, Jones, Mathew J.K., Richard, Derek J., Forrest, Alistair, Spurdle, Amanda, Verdin, Eric, Crossley, Merlin, Fanciulli, Maurizio, Chenevix-Trench, Georgia, Young, David B. and Khanna, Kum Kum (2007). A novel corepressor, BCoR-L1, represses transcription through an interaction with CtBP. Journal of Biological Chemistry, 282 (20), 15248-15257. doi: 10.1074/jbc.M700246200

Kay, J. G., Murray, R. Z., Pagan, J. K. and Stow, J. L. (2006). Cytokine secretion via cholesterol-rich lipid raft-associated SNAREs at the phagocytic cup. Journal of Biological Chemistry, 281 (17), 11949-11954. doi: 10.1074/jbc.M600857200

Pagan, J. K., Wylie, F. G., Joseph, S. R., Widberg, C., Bryant, N. J., James, D. E. and Stow, J. L. (2003). The t-SNARE syntaxin 4 is regulated during macrophage activation to function in membrane traffic and cytokine secretion. Current Biology, 13 (2), 156-160. doi: 10.1016/S0960-9822(03)00006-X

Shurety, Wenda, Pagan, Julia K., Prins, Johannes B. and Stow, Jennifer L. (2001). Endocytosis of uncleaved tumor necrosis factor-alpha in macrophages. Laboratory Investigation, 81 (1), 107-117. doi: 10.1038/labinvest.3780216

Pagan, J. K., Wylie, F. G. and Stow, J. L. (2002). Regulation of TNF trafficking in macrophages. 42nd Annual Meeting of the American-Society-for-Cell-Biology, San Francisco California, 14-18 December 2002. Bethesda, MD United States: American Society for Cell Biology.

Dr Julia Pagan

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